Stabilizing Microtubules Decreases Myocardial Ischaemia-Reperfusion Injury

Anaesthesia and myocardial ischaemia/reperfusion injury

Anaesthetists are confronted on a daily basis with patients with coronary artery disease, myocardial ischaemia, or both during the perioperative period. Therefore, prevention and ultimately adequate therapy of perioperative myocardial ischaemia and its consequences are the major challenges in current anaesthetic practice. This review will focus on the translation of the laboratory evidence of a...

Anaesthesia and myocardial ischaemia/reperfusion injury.

Anaesthetists are confronted on a daily basis with patients with coronary artery disease, myocardial ischaemia, or both during the perioperative period. Therefore, prevention and ultimately adequate therapy of perioperative myocardial ischaemia and its consequences are the major challenges in current anaesthetic practice. This review will focus on the translation of the laboratory evidence of a...

The Involvement of CaMKII in Myocardial Ischaemia-Reperfusion Injury

The cardioprotective potential of valsartan in myocardial ischaemia reperfusion injury

BACKGROUND Ischaemia/reperfusion injury describes the experimentally and clinically prevalent finding that tissue ischaemia with inadequate oxygen followed by successful reperfusion initiates a wide and complex array of inflammatory responses that may aggravate local injury as well as induce impairment of remote organ function by mechanisms that involve oxidative stress, inflammation, and apopt...

Pharmacological interventions against myocardial ischaemia and reperfusion injury

Background: Although the concept of early restoration of coronary bloodflow constitutes an important factor to reduce the injury caused by myocardial ischaemia, reperfusion in itself can aggravate the damage to myocardial tissue, a phenomenon denoted myocardial reperfusion injury. Aims: To investigate whether two different pharmacological interventions, cyclosporine A (CsA) and the novel enkeph...